A study conducted by researchers from Beijing, China demonstrates efficacy for the multi-component Chinese herbal formula with the herb, Qing Luo Yin.
This study conducted by Bo Zhang, Xu Wang, and Shao Li from the Bioinformatics Division and Center for Synthetic and Systems Biology at Tsinghua University in Beijing, China, not only revealed the target network of the herbal formula Qing Luo Yin against rheumatoid arthritis (RA) related key processes including angiogenesis, inflammatory response, immune response and NF-kappaB activity, but also predicted corresponding active and synergistic ingredients.
It found that the herb Ku Shen and three others may synergize by targeting inflammation, angiogenesis and immune system, especially acting on the compensatory pathway and feedback loop in the TNF, IL1B and VEGF pathways. The herb Huang Bai may antagonize the adverse reaction of Ku Shen possibly by targeting some off-target genes (i.e., PTGS1).
These findings are either verified by literature evidence or have the potential to guide further experiments. The network-based strategy put forth by Zhang is expected to eventually make the systematical study of herbal formula achievable and make the TCM drug discovery predictable.
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